Most Influential SCIENCE Papers (2025-09 Version)
Science, also widely referred to as Science Magazine, is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world’s top academic journals. Paper Digest Team analyze all papers published on SCIENCE in the past years, and presents the 10 most influential papers for each year (based on when the paper became available online). This ranking list is automatically constructed based upon citations from both research papers and granted patents, and will be frequently updated to reflect the most recent changes. To find the most influential papers from other conferences/journals, visit Best Paper Digest page. Note: the most influential papers may or may not include the papers that won the best paper awards. (Version: 2025-09)
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TABLE 1: Most Influential SCIENCE Papers (2025-09 Version)
| Year | Rank | Paper | Author(s) |
|---|---|---|---|
| 2025 | 1 | Simulating 500 Million Years of Evolution with A Language Model IF:5 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: More than 3 billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here, we show that language models trained at scale on … |
THOMAS HAYES et. al. |
| 2025 | 2 | Global Soil Pollution By Toxic Metals Threatens Agriculture and Human Health IF:3 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: We analyzed a global database of soil pollution by arsenic, cadmium, cobalt, chromium, copper, nickel, and lead at 796,084 sampling points from 1493 regional studies and used machine learning techniques to map areas with exceedance of agricultural and human health thresholds. |
DEYI HOU et. al. |
| 2025 | 3 | Random Unitaries in Extremely Low Depth IF:3 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: In this work, we prove that local quantum circuits can form random unitaries in extremely low depth on any geometry. |
Thomas Schuster; Jonas Haferkamp; Hsin-Yuan Huang; |
| 2025 | 4 | Direct Neutrino-mass Measurement Based on 259 Days of KATRIN Data IF:3 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: We report on the search for the effective electron antineutrino mass with the KATRIN experiment. |
MAX AKER et. al. |
| 2025 | 5 | Tantalum-stabilized Ruthenium Oxide Electrocatalysts for Industrial Water Electrolysis IF:3 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: We used well-defined extended surface models to identify that RuO undergoes structure-dependent corrosion that causes Ru dissolution. |
JIAHAO ZHANG et. al. |
| 2025 | 6 | Rapid in Silico Directed Evolution By A Protein Language Model with EVOLVEpro IF:3 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Directed protein evolution is central to biomedical applications but faces challenges such as experimental complexity, inefficient multiproperty optimization, and local maxima … |
KAIYI JIANG et. al. |
| 2025 | 7 | Scalable Emulation of Protein Equilibrium Ensembles with Generative Deep Learning IF:3 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Following the sequence and structure revolutions, predicting functionally relevant protein structure changes at scale remains an outstanding challenge. We introduce BioEmu, a deep … |
SARAH LEWIS et. al. |
| 2025 | 8 | Beyond-classical Computation in Quantum Simulation IF:3 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Quantum computers hold the promise of solving certain problems that lie beyond the reach of conventional computers. However, establishing this capability, especially for impactful … |
ANDREW D KING et. al. |
| 2025 | 9 | Ultrastable Supported Oxygen Evolution Electrocatalyst Formed By Ripening-induced Embedding IF:3 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: Here we present a ripening-induced embedding strategy that securely embeds the Ir catalyst in a cerium oxide support. |
WENJUAN SHI et. al. |
| 2025 | 10 | Quadruple-band Synglisis Enables High Thermoelectric Efficiency in Earth-abundant Tin Sulfide Crystals IF:3 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: We introduced more Sn vacancies to activate quadruple-band synglisis and facilitate carrier transport by inducing SnS in selenium (Se)-alloyed SnS, leading to a high dimensionless figure of merit ( ) of ~1.0 at 300 kelvin and an average of ~1.3 at 300 to 773 kelvin in p-type SnS crystals. |
SHAN LIU et. al. |
| 2024 | 1 | Improved Charge Extraction in Inverted Perovskite Solar Cells with Dual-site-binding Ligands IF:7 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: We fabricated pin PSCs and report a certified quasi-steady state PCE of 26.15 and 24.74% for 0.05- and 1.04-square centimeter illuminated areas, respectively. |
HAO CHEN et. al. |
| 2024 | 2 | Generalized Biomolecular Modeling and Design with RoseTTAFold All-Atom IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Deep-learning methods have revolutionized protein structure prediction and design but are presently limited to protein-only systems. We describe RoseTTAFold All-Atom (RFAA), which … |
ROHITH KRISHNA et. al. |
| 2024 | 3 | Managing Extreme AI Risks Amid Rapid Progress IF:5 Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Preparation requires technical research and development, as well as adaptive, proactive governance. … |
YOSHUA BENGIO et. al. |
| 2024 | 4 | Persistent Complement Dysregulation with Signs of Thromboinflammation in Active Long Covid IF:5 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after … |
CARLO CERVIA-HASLER et. al. |
| 2024 | 5 | Reinforcing Self-assembly of Hole Transport Molecules for Stable Inverted Perovskite Solar Cells IF:4 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: We found that strong polar solvents in the perovskite precursor desorb the SAM if it is anchored on substrates by hydrogen-bonded, rather than covalently bonded, hydroxyl groups. |
HONGCAI TANG et. al. |
| 2024 | 6 | Structural Disorder Determines Capacitance in Nanoporous Carbons IF:4 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The difficulty in characterizing the complex structures of nanoporous carbon electrodes has led to a lack of clear design principles with which to improve supercapacitors. Pore … |
XINYU LIU et. al. |
| 2024 | 7 | Deterministic Reprogramming of Neutrophils Within Tumors IF:4 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the … |
MELISSA S F NG et. al. |
| 2024 | 8 | Pathways Toward Commercial Perovskite/silicon Tandem Photovoltaics IF:4 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: In addition, perovskite/silicon tandem research needs to increasingly focus on stability, reliability, throughput of cell production and characterization, cell-to-module integration, and accurate field-performance prediction and evaluation. This Review discusses these aspects in view of contemporary solar cell manufacturing, offers insights into the possible pathways toward commercial perovskite/silicon tandem photovoltaics, and highlights research opportunities to realize this goal. |
ERKAN AYDIN et. al. |
| 2024 | 9 | Ultrahigh Energy Storage in High-entropy Ceramic Capacitors with Polymorphic Relaxor Phase IF:4 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: We propose a high-entropy design in barium titanate (BaTiO )-based lead-free MLCCs with polymorphic relaxor phase. |
MIN ZHANG et. al. |
| 2024 | 10 | Sequence Modeling and Design from Molecular to Genome Scale with Evo IF:4 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The genome is a sequence that encodes the DNA, RNA, and proteins that orchestrate an organism’s function. We present Evo, a long-context genomic foundation model with a frontier … |
ERIC NGUYEN et. al. |
| 2023 | 1 | ChatGPT Is Fun, But Not An Author IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: In less than 2 months, the artificial intelligence (AI) program ChatGPT has become a cultural sensation. It is freely accessible through a web portal created by the tool’s … |
H Holden Thorp; |
| 2023 | 2 | Accurate Proteome-wide Missense Variant Effect Prediction with AlphaMissense IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The vast majority of missense variants observed in the human genome are of unknown clinical significance. We present AlphaMissense, an adaptation of AlphaFold fine-tuned on human … |
JUN CHENG et. al. |
| 2023 | 3 | Learning Skillful Medium-range Global Weather Forecasting IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Global medium-range weather forecasting is critical to decision-making across many social and economic domains. Traditional numerical weather prediction uses increased compute … |
REMI LAM et. al. |
| 2023 | 4 | Experimental Evidence on The Productivity Effects of Generative Artificial Intelligence IF:7 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: We examined the productivity effects of a generative artificial intelligence (AI) technology, the assistive chatbot ChatGPT, in the context of midlevel professional writing tasks. |
Shakked Noy; Whitney Zhang; |
| 2023 | 5 | CRISPR Technology: A Decade of Genome Editing Is Only The Beginning IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The advent of clustered regularly interspaced short palindromic repeat (CRISPR) genome editing, coupled with advances in computing and imaging capabilities, has initiated a new … |
Joy Y Wang; Jennifer A Doudna; |
| 2023 | 6 | Minimizing Buried Interfacial Defects for Efficient Inverted Perovskite Solar Cells IF:7 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: In this work, we report an amphiphilic molecular hole transporter, (2-(4-(bis(4-methoxyphenyl)amino)phenyl)-1-cyanovinyl)phosphonic acid, that features a multifunctional cyanovinyl phosphonic acid group and forms a superwetting underlayer for perovskite deposition, which enables high-quality perovskite films with minimized defects at the buried interface. |
SHUO ZHANG et. al. |
| 2023 | 7 | Neuromorphic Sensorimotor Loop Embodied By Monolithically Integrated, Low-voltage, Soft E-skin IF:6 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Artificial skin that simultaneously mimics sensory feedback and mechanical properties of natural skin holds substantial promise for next-generation robotic and medical devices. … |
WEICHEN WANG et. al. |
| 2023 | 8 | A Global Transition to Flash Droughts Under Climate Change IF:6 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: In this study, we show that drought intensification rates have sped up over subseasonal time scales and that there has been a transition toward more flash droughts over 74% of the global regions identified by the Intergovernmental Panel on Climate Change Special Report on Extreme Events during the past 64 years. |
XING YUAN et. al. |
| 2023 | 9 | Direct Synthesis and Chemical Vapor Deposition of 2D Carbide and Nitride MXenes IF:6 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: We demonstrate a direct synthetic route for scalable and atom-economic synthesis of MXenes, including compounds that have not been synthesized from MAX phases, by the reactions of metals and metal halides with graphite, methane, or nitrogen. |
DI WANG et. al. |
| 2023 | 10 | Art and The Science of Generative AI IF:6 Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Understanding shifts in creative work will help guide AI’s impact on the media ecosystem. … |
ZIV EPSTEIN et. al. |
| 2022 | 1 | Copper Induces Cell Death By Targeting Lipoylated TCA Cycle Proteins IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How … |
PETER TSVETKOV et. al. |
| 2022 | 2 | The Complete Sequence of A Human Genome IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. … |
SERGEY NURK et. al. |
| 2022 | 3 | Competition-level Code Generation with AlphaCode IF:8 Related Papers Related Patents Related Grants Related Venues Related Experts View Highlight: Here, we introduce AlphaCode, a system for code generation that achieved an average ranking in the top 54.3% in simulated evaluations on recent programming competitions on the Codeforces platform. |
YUJIA LI et. al. |
| 2022 | 4 | Longitudinal Analysis Reveals High Prevalence of Epstein-Barr Virus Associated with Multiple Sclerosis IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by … |
KJETIL BJORNEVIK et. al. |
| 2022 | 5 | Exceeding 1.5°C Global Warming Could Trigger Multiple Climate Tipping Points IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Climate tipping points occur when change in a part of the climate system becomes self-perpetuating beyond a warming threshold, leading to substantial Earth system impacts. … |
DAVID I ARMSTRONG MCKAY et. al. |
| 2022 | 6 | Per- and Polyfluoroalkyl Substances in The Environment IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Over the past several years, the term PFAS (per- and polyfluoroalkyl substances) has grown to be emblematic of environmental contamination, garnering public, scientific, and … |
MARINA G EVICH et. al. |
| 2022 | 7 | CAR T Cells Produced in Vivo to Treat Cardiac Injury IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Fibrosis affects millions of people with cardiac disease. We developed a therapeutic approach to generate transient antifibrotic chimeric antigen receptor (CAR) T cells in vivo by … |
JOEL G RURIK et. al. |
| 2022 | 8 | Grassland Soil Carbon Sequestration: Current Understanding, Challenges, and Solutions IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Grasslands store approximately one third of the global terrestrial carbon stocks and can act as an important soil carbon sink. Recent studies show that plant diversity increases … |
Yongfei Bai; M Francesca Cotrufo; |
| 2022 | 9 | Tertiary Lymphoid Structures in Cancer IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Ectopic lymphoid aggregates, termed tertiary lymphoid structures (TLSs), are formed in numerous cancer types, and, with few exceptions, their presence is associated with superior … |
Ton N Schumacher; Daniela S Thommen; |
| 2022 | 10 | Early Detection of Cancer IF:7 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Survival improves when cancer is detected early. However, ~50% of cancers are at an advanced stage when diagnosed. Early detection of cancer or precancerous change allows early … |
DAVID CROSBY et. al. |
| 2021 | 1 | Accurate Prediction of Protein Structures and Interactions Using A 3-track Neural Network IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Deep learning takes on protein folding In 1972, Anfinsen won a Nobel prize for demonstrating a connection between a protein’s amino acid sequence and its three-dimensional … |
MINKYUNG BAEK et. al. |
| 2021 | 2 | Immunological Memory to SARS-CoV-2 Assessed for Up to 8 Months After Infection IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Understanding immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics and vaccines and for assessing the likely future … |
JENNIFER M DAN et. al. |
| 2021 | 3 | Estimated Transmissibility and Impact of SARS-CoV-2 Lineage B.1.1.7 in England IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, VOC 202012/01 (lineage B.1.1.7), emerged in southeast England in September 2020 and is rapidly spreading … |
NICHOLAS G DAVIES et. al. |
| 2021 | 4 | Accurate Prediction of Protein Structures and Interactions Using A Three-track Neural Network IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of Structure Prediction (CASP14) conference. We explored network architectures that … |
MINKYUNG BAEK et. al. |
| 2021 | 5 | The World of Two-dimensional Carbides and Nitrides (MXenes) IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: A decade after the first report, the family of two-dimensional (2D) carbides and nitrides (MXenes) includes structures with three, five, seven, or nine layers of atoms in an … |
Armin VahidMohammadi; Johanna Rosen; Yury Gogotsi; |
| 2021 | 6 | The Global Threat from Plastic Pollution IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Plastic pollution accumulating in an area of the environment is considered poorly reversible if natural mineralization processes occurring there are slow and engineered … |
Matthew MacLeod; Hans Peter H Arp; Mine B Tekman; Annika Jahnke; |
| 2021 | 7 | Genomics and Epidemiology of The P.1 SARS-CoV-2 Lineage in Manaus, Brazil IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome … |
NUNO R FARIA et. al. |
| 2021 | 8 | Semiconductor Quantum Dots: Technological Progress and Future Challenges IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: In quantum-confined semiconductor nanostructures, electrons exhibit distinctive behavior compared with that in bulk solids. This enables the design of materials with tunable … |
F PELAYO GARCÍA DE ARQUER et. al. |
| 2021 | 9 | Material-structure-performance Integrated Laser-metal Additive Manufacturing IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Laser-metal additive manufacturing capabilities have advanced from single-material printing to multimaterial/multifunctional design and manufacturing. … |
DONGDONG GU et. al. |
| 2021 | 10 | Airborne Transmission of Respiratory Viruses IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The COVID-19 pandemic has revealed critical knowledge gaps in our understanding of and a need to update the traditional view of transmission pathways for respiratory viruses. The … |
CHIA C WANG et. al. |
| 2020 | 1 | Cryo-EM Structure Of The 2019-nCoV Spike In The Prefusion Conformation IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) … |
DANIEL WRAPP et. al. |
| 2020 | 2 | The Biology , Function , And Biomedical Applications Of Exosomes IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The study of extracellular vesicles (EVs) has the potential to identify unknown cellular and molecular mechanisms in intercellular communication and in organ homeostasis and … |
Raghu Kalluri; Valerie S LeBleu; |
| 2020 | 3 | Structural Basis For The Recognition Of SARS-CoV-2 By Full-length Human ACE2 IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for severe acute respiratory syndrome-coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2) that is causing … |
RENHONG YAN et. al. |
| 2020 | 4 | Substantial Undocumented Infection Facilitates The Rapid Dissemination of Novel Coronavirus (SARS-CoV-2) IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Estimation of the prevalence and contagiousness of undocumented novel coronavirus [severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)] infections is critical for … |
RUIYUN LI et. al. |
| 2020 | 5 | The Effect of Travel Restrictions on The Spread of The 2019 Novel Coronavirus (COVID-19) Outbreak IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Motivated by the rapid spread of coronavirus disease 2019 (COVID-19) in mainland China, we use a global metapopulation disease transmission model to project the impact of travel … |
MATTEO CHINAZZI et. al. |
| 2020 | 6 | The Effect of Human Mobility and Control Measures on The COVID-19 Epidemic in China IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The ongoing coronavirus disease 2019 (COVID-19) outbreak expanded rapidly throughout China. Major behavioral, clinical, and state interventions were undertaken to mitigate the … |
MORITZ U G KRAEMER et. al. |
| 2020 | 7 | Crystal Structure of SARS-CoV-2 Main Protease Provides A Basis for Design of Improved Α-ketoamide Inhibitors IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug target … |
LINLIN ZHANG et. al. |
| 2020 | 8 | Impaired Type I Interferon Activity and Inflammatory Responses in Severe COVID-19 Patients IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease progression that suggest diverse host immune responses. We performed an integrated immune … |
JÉRÔME HADJADJ et. al. |
| 2020 | 9 | Projecting The Transmission Dynamics of SARS-CoV-2 Through The Postpandemic Period IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: It is urgent to understand the future of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) transmission. We used estimates of seasonality, immunity, and cross-immunity … |
Stephen M Kissler; Christine Tedijanto; Edward Goldstein; Yonatan H Grad; Marc Lipsitch; |
| 2020 | 10 | Quantifying SARS-CoV-2 Transmission Suggests Epidemic Control with Digital Contact Tracing IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The newly emergent human virus SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) is resulting in high fatality rates and incapacitated health systems. Preventing … |
LUCA FERRETTI et. al. |
| 2019 | 1 | Dissecting Racial Bias in An Algorithm Used to Manage The Health of Populations IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Health systems rely on commercial prediction algorithms to identify and help patients with complex health needs. We show that a widely used algorithm, typical of this … |
Ziad Obermeyer; Brian Powers; Christine Vogeli; Sendhil Mullainathan; |
| 2019 | 2 | Tuning Superconductivity In Twisted Bilayer Graphene IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Materials with flat electronic bands often exhibit exotic quantum phenomena owing to strong correlations. An isolated low-energy flat band can be induced in bilayer graphene by … |
MATTHEW YANKOWITZ et. al. |
| 2019 | 3 | What Would It Take For Renewably Powered Electrosynthesis To Displace Petrochemical Processes? IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Electrocatalytic transformation of carbon dioxide (CO ) and water into chemical feedstocks offers the potential to reduce carbon emissions by shifting the chemical industry away … |
PHIL DE LUNA et. al. |
| 2019 | 4 | Slide-seq: A Scalable Technology for Measuring Genome-wide Expression at High Spatial Resolution IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Spatial positions of cells in tissues strongly influence function, yet a high-throughput, genome-wide readout of gene expression with cellular resolution is lacking. We developed … |
SAMUEL G RODRIQUES et. al. |
| 2019 | 5 | Exceptional Points In Optics And Photonics IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Exceptional points are branch point singularities in the parameter space of a system at which two or more eigenvalues, and their corresponding eigenvectors, coalesce and become … |
Mohammad-Ali Miri; Andrea Alù; |
| 2019 | 6 | Pervasive Human-driven Decline Of Life On Earth Points To The Need For Transformative Change IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The human impact on life on Earth has increased sharply since the 1970s, driven by the demands of a growing population with rising average per capita income. Nature is currently … |
SANDRA DÍAZ et. al. |
| 2019 | 7 | Metabolic Reprogramming and Cancer Progression IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Metabolic reprogramming is a hallmark of malignancy. As our understanding of the complexity of tumor biology increases, so does our appreciation of the complexity of tumor … |
Brandon Faubert; Ashley Solmonson; Ralph J DeBerardinis; |
| 2019 | 8 | The Human Tumor Microbiome Is Composed of Tumor Type-specific Intracellular Bacteria IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We … |
DEBORAH NEJMAN et. al. |
| 2019 | 9 | Emergent Ferromagnetism Near Three-quarters Filling In Twisted Bilayer Graphene IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: When two sheets of graphene are stacked at a small twist angle, the resulting flat superlattice minibands are expected to strongly enhance electron-electron interactions. Here, we … |
AARON L SHARPE et. al. |
| 2019 | 10 | The Global Tree Restoration Potential IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The restoration of trees remains among the most effective strategies for climate change mitigation. We mapped the global potential tree coverage to show that 4.4 billion hectares … |
JEAN-FRANCOIS BASTIN et. al. |
| 2018 | 1 | Cancer Immunotherapy Using Checkpoint Blockade IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The release of negative regulators of immune activation (immune checkpoints) that limit antitumor responses has resulted in unprecedented rates of long-lasting tumor responses in … |
Antoni Ribas; Jedd D Wolchok; |
| 2018 | 2 | A General Reinforcement Learning Algorithm That Masters Chess, Shogi, And Go Through Self-play IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The game of chess is the longest-studied domain in the history of artificial intelligence. The strongest programs are based on a combination of sophisticated search techniques, … |
DAVID SILVER et. al. |
| 2018 | 3 | The Science Of Fake News IF:8 Related Papers Related Patents Related Grants Related Venues Related Experts View |
DAVID M J LAZER et. al. |
| 2018 | 4 | CRISPR-Cas12a Target Binding Unleashes Indiscriminate Single-stranded DNase Activity IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: CRISPR-Cas12a (Cpf1) proteins are RNA-guided enzymes that bind and cut DNA as components of bacterial adaptive immune systems. Like CRISPR-Cas9, Cas12a has been harnessed for … |
JANICE S CHEN et. al. |
| 2018 | 5 | Shifting The Limits in Wheat Research and Breeding Using A Fully Annotated Reference Genome IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding … |
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| 2018 | 6 | CAR T Cell Immunotherapy for Human Cancer IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field … |
Carl H June; Roddy S O’Connor; Omkar U Kawalekar; Saba Ghassemi; Michael C Milone; |
| 2018 | 7 | Organic And Solution-processed Tandem Solar Cells With 17.3% Efficiency IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Although organic photovoltaic (OPV) cells have many advantages, their performance still lags far behind that of other photovoltaic platforms. A fundamental reason for their low … |
LINGXIAN MENG et. al. |
| 2018 | 8 | Detection and Localization of Surgically Resectable Cancers with A Multi-analyte Blood Test IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating … |
JOSHUA D COHEN et. al. |
| 2018 | 9 | Declining Oxygen In The Global Ocean And Coastal Waters IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Oxygen is fundamental to life. Not only is it essential for the survival of individual animals, but it regulates global cycles of major nutrients and carbon. The oxygen content of … |
DENISE BREITBURG et. al. |
| 2018 | 10 | Assessing Nature’s Contributions To People IF:8 Related Papers Related Patents Related Grants Related Venues Related Experts View |
SANDRA DÍAZ et. al. |
| 2017 | 1 | Combining Theory And Experiment In Electrocatalysis: Insights Into Materials Design IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Electrocatalysis plays a central role in clean energy conversion, enabling a number of sustainable processes for future technologies. This review discusses design strategies for … |
ZHI WEI SEH et. al. |
| 2017 | 2 | The Spread of True and False News Online IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: We investigated the differential diffusion of all of the verified true and false news stories distributed on Twitter from 2006 to 2017. The data comprise ~126,000 stories tweeted … |
Soroush Vosoughi; Deb Roy; Sinan Aral; |
| 2017 | 3 | Mismatch Repair Deficiency Predicts Response of Solid Tumors to PD-1 Blockade IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed that colorectal … |
DUNG T LE et. al. |
| 2017 | 4 | Iodide Management In Formamidinium-lead-halide-based Perovskite Layers For Efficient Solar Cells IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The formation of a dense and uniform thin layer on the substrates is crucial for the fabrication of high-performance perovskite solar cells (PSCs) containing formamidinium with … |
WOON SEOK YANG et. al. |
| 2017 | 5 | Gut Microbiome Influences Efficacy Of PD-1-based Immunotherapy Against Epithelial Tumors IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizable minority of cancer patients. We found that primary resistance to … |
BERTRAND ROUTY et. al. |
| 2017 | 6 | Gut Microbiome Modulates Response to Anti-PD-1 Immunotherapy in Melanoma Patients IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Preclinical mouse models suggest that the gut microbiome modulates tumor response to checkpoint blockade immunotherapy; however, this has not been well-characterized in human … |
V GOPALAKRISHNAN et. al. |
| 2017 | 7 | Liquid Phase Condensation In Cell Physiology And Disease IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Phase transitions are ubiquitous in nonliving matter, and recent discoveries have shown that they also play a key role within living cells. Intracellular liquid-liquid phase … |
Yongdae Shin; Clifford P Brangwynne; |
| 2017 | 8 | Nucleic Acid Detection with CRISPR-Cas13a/C2c2 IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen detection, genotyping, and disease monitoring. The RNA-guided, RNA-targeting clustered … |
JONATHAN S GOOTENBERG et. al. |
| 2017 | 9 | A Pathology Atlas Of The Human Cancer Transcriptome IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of … |
MATHIAS UHLEN et. al. |
| 2017 | 10 | Biodiversity Redistribution Under Climate Change: Impacts On Ecosystems And Human Well-being IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Distributions of Earth’s species are changing at accelerating rates, increasingly driven by human-mediated climate change. Such changes are already altering the composition of … |
GRETTA T PECL et. al. |
| 2016 | 1 | 2D Materials And Van Der Waals Heterostructures IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The physics of two-dimensional (2D) materials and heterostructures based on such crystals has been developing extremely fast. With these new materials, truly 2D physics has begun … |
K S Novoselov; A Mishchenko; A Carvalho; A H Castro Neto; |
| 2016 | 2 | Electromagnetic Interference Shielding With 2D Transition Metal Carbides (MXenes) IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Materials with good flexibility and high conductivity that can provide electromagnetic interference (EMI) shielding with minimal thickness are highly desirable, especially if they … |
FAISAL SHAHZAD et. al. |
| 2016 | 3 | Active Sites Of Nitrogen-doped Carbon Materials For Oxygen Reduction Reaction Clarified Using Model Catalysts IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Nitrogen (N)-doped carbon materials exhibit high electrocatalytic activity for the oxygen reduction reaction (ORR), which is essential for several renewable energy systems. … |
DONGHUI GUO et. al. |
| 2016 | 4 | Incorporation Of Rubidium Cations Into Perovskite Solar Cells Improves Photovoltaic Performance IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: All of the cations currently used in perovskite solar cells abide by the tolerance factor for incorporation into the lattice. We show that the small and oxidation-stable rubidium … |
MICHAEL SALIBA et. al. |
| 2016 | 5 | Metalenses At Visible Wavelengths: Diffraction-limited Focusing And Subwavelength Resolution Imaging IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Subwavelength resolution imaging requires high numerical aperture (NA) lenses, which are bulky and expensive. Metasurfaces allow the miniaturization of conventional refractive … |
MOHAMMADREZA KHORASANINEJAD et. al. |
| 2016 | 6 | Semantics Derived Automatically From Language Corpora Contain Human-like Biases IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Machine learning is a means to derive artificial intelligence by discovering patterns in existing data. Here, we show that applying machine learning to ordinary human language … |
Aylin Caliskan; Joanna J Bryson; Arvind Narayanan; |
| 2016 | 7 | Visualization And Analysis Of Gene Expression In Tissue Sections By Spatial Transcriptomics IF:10 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Analysis of the pattern of proteins or messengerRNAs (mRNAs) in histological tissue sections is a cornerstone in biomedical research and diagnostics. This typically involves the … |
PATRIK L STÅHL et. al. |
| 2016 | 8 | Clonal Neoantigens Elicit T Cell Immunoreactivity and Sensitivity to Immune Checkpoint Blockade IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored the impact of … |
NICHOLAS MCGRANAHAN et. al. |
| 2016 | 9 | A Mixed-cation Lead Mixed-halide Perovskite Absorber For Tandem Solar Cells IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Metal halide perovskite photovoltaic cells could potentially boost the efficiency of commercial silicon photovoltaic modules from ∼20 toward 30% when used in tandem architectures. … |
DAVID P MCMEEKIN et. al. |
| 2016 | 10 | Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Models IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Synapse loss in Alzheimer’s disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late … |
SOYON HONG et. al. |
| 2015 | 1 | Machine Learning: Trends, Perspectives, And Prospects IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Machine learning addresses the question of how to build computers that improve automatically through experience. It is one of today’s most rapidly growing technical fields, lying … |
M I Jordan; T M Mitchell; |
| 2015 | 2 | Neoantigens in Cancer Immunotherapy IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The clinical relevance of T cells in the control of a diverse set of human cancers is now beyond doubt. However, the nature of the antigens that allow the immune system to … |
Ton N Schumacher; Robert D Schreiber; |
| 2015 | 3 | The Future Of Immune Checkpoint Therapy IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Immune checkpoint therapy, which targets regulatory pathways in T cells to enhance antitumor immune responses, has led to important clinical advances and provided a new weapon … |
Padmanee Sharma; James P Allison; |
| 2015 | 4 | Dissecting The Multicellular Ecosystem of Metastatic Melanoma By Single-cell RNA-seq IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, … |
ITAY TIROSH et. al. |
| 2015 | 5 | Bee Declines Driven By Combined Stress From Parasites, Pesticides, And Lack Of Flowers IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Bees are subject to numerous pressures in the modern world. The abundance and diversity of flowers has declined; bees are chronically exposed to cocktails of agrochemicals, and … |
Dave Goulson; Elizabeth Nicholls; Cristina Botías; Ellen L Rotheray; |
| 2015 | 6 | Commensal Bifidobacterium Promotes Antitumor Immunity And Facilitates Anti-PD-L1 Efficacy IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: T cell infiltration of solid tumors is associated with favorable patient outcomes, yet the mechanisms underlying variable immune responses between individuals are not well … |
AYELET SIVAN et. al. |
| 2015 | 7 | Human-level Concept Learning Through Probabilistic Program Induction IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: People learning new concepts can often generalize successfully from just a single example, yet machine learning algorithms typically require tens or hundreds of examples to … |
Brenden M Lake; Ruslan Salakhutdinov; Joshua B Tenenbaum; |
| 2015 | 8 | Anticancer Immunotherapy By CTLA-4 Blockade Relies On The Gut Microbiota IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In … |
MARIE VÉTIZOU et. al. |
| 2015 | 9 | Genomic Correlates of Response to CTLA-4 Blockade in Metastatic Melanoma IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Monoclonal antibodies directed against cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), such as ipilimumab, yield considerable clinical benefit for patients with metastatic … |
ELIEZER M VAN ALLEN et. al. |
| 2015 | 10 | Overcoming The Electroluminescence Efficiency Limitations Of Perovskite Light-emitting Diodes IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Organic-inorganic hybrid perovskites are emerging low-cost emitters with very high color purity, but their low luminescent efficiency is a critical drawback. We boosted the … |
HIMCHAN CHO et. al. |
| 2014 | 1 | A Fracture-resistant High-entropy Alloy For Cryogenic Applications IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: High-entropy alloys are equiatomic, multi-element systems that can crystallize as a single phase, despite containing multiple elements with different crystal structures. A … |
BERND GLUDOVATZ et. al. |
| 2014 | 2 | Single-cell RNA-seq Highlights Intratumoral Heterogeneity in Primary Glioblastoma IF:10 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes, and epigenetic states, but current models do not adequately reflect tumor composition … |
ANOOP P PATEL et. al. |
| 2014 | 3 | Lignin Valorization: Improving Lignin Processing In The Biorefinery IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Research and development activities directed toward commercial production of cellulosic ethanol have created the opportunity to dramatically increase the transformation of lignin … |
ARTHUR J RAGAUSKAS et. al. |
| 2014 | 4 | Defaunation In The Anthropocene IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: We live amid a global wave of anthropogenically driven biodiversity loss: species and population extirpations and, critically, declines in local species abundance. Particularly, … |
RODOLFO DIRZO et. al. |
| 2014 | 5 | The Biodiversity Of Species And Their Rates Of Extinction, Distribution, And Protection IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Recent studies clarify where the most vulnerable species live, where and how humanity changes the planet, and how this drives extinctions. We assess key statistics about species, … |
S L PIMM et. al. |
| 2014 | 6 | A Hole-conductor-free, Fully Printable Mesoscopic Perovskite Solar Cell With High Stability IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: We fabricated a perovskite solar cell that uses a double layer of mesoporous TiO2 and ZrO2 as a scaffold infiltrated with perovskite and does not require a hole-conducting layer. … |
ANYI MEI et. al. |
| 2014 | 7 | Nanoporous BiVO4 Photoanodes With Dual-layer Oxygen Evolution Catalysts For Solar Water Splitting IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Bismuth vanadate (BiVO4) has a band structure that is well-suited for potential use as a photoanode in solar water splitting, but it suffers from poor electron-hole separation. … |
Tae Woo Kim; Kyoung-Shin Choi; |
| 2014 | 8 | Highly Crystalline Multimetallic Nanoframes With Three-dimensional Electrocatalytic Surfaces IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Control of structure at the atomic level can precisely and effectively tune catalytic properties of materials, enabling enhancement in both activity and durability. We synthesized … |
CHEN CHEN et. al. |
| 2014 | 9 | Organogenesis In A Dish: Modeling Development And Disease Using Organoid Technologies IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Classical experiments performed half a century ago demonstrated the immense self-organizing capacity of vertebrate cells. Even after complete dissociation, cells can reaggregate … |
Madeline A Lancaster; Juergen A Knoblich; |
| 2014 | 10 | Phylogenomics Resolves The Timing and Pattern of Insect Evolution IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Insects are the most speciose group of animals, but the phylogenetic relationships of many major lineages remain unresolved. We inferred the phylogeny of insects from 1478 … |
BERNHARD MISOF et. al. |
| 2013 | 1 | Multiplex Genome Engineering Using CRISPR/Cas Systems IF:10 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short … |
LE CONG et. al. |
| 2013 | 2 | The Chemistry And Applications Of Metal-organic Frameworks IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Crystalline metal-organic frameworks (MOFs) are formed by reticular synthesis, which creates strong bonds between inorganic and organic units. Careful selection of MOF … |
Hiroyasu Furukawa; Kyle E Cordova; Michael O’Keeffe; Omar M Yaghi; |
| 2013 | 3 | High-resolution Global Maps Of 21st-century Forest Cover Change IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Quantification of global forest change has been lacking despite the recognized importance of forest ecosystem services. In this study, Earth observation satellite data were used … |
M C HANSEN et. al. |
| 2013 | 4 | RNA-guided Human Genome Engineering Via Cas9 IF:10 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Bacteria and archaea have evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems, that use … |
PRASHANT MALI et. al. |
| 2013 | 5 | Electron-hole Diffusion Lengths Exceeding 1 Micrometer In An Organometal Trihalide Perovskite Absorber IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Organic-inorganic perovskites have shown promise as high-performance absorbers in solar cells, first as a coating on a mesoporous metal oxide scaffold and more recently as a solid … |
SAMUEL D STRANKS et. al. |
| 2013 | 6 | Long-range Balanced Electron- And Hole-transport Lengths In Organic-inorganic CH3NH3PbI3 IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Low-temperature solution-processed photovoltaics suffer from low efficiencies because of poor exciton or electron-hole diffusion lengths (typically about 10 nanometers). Recent … |
GUICHUAN XING et. al. |
| 2013 | 7 | Genome-scale CRISPR-Cas9 Knockout Screening in Human Cells IF:10 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The simplicity of programming the CRISPR (clustered regularly interspaced short palindromic repeats)-associated nuclease Cas9 to modify specific genomic loci suggests a new way to … |
OPHIR SHALEM et. al. |
| 2013 | 8 | Carbon Nanotubes: Present And Future Commercial Applications IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Worldwide commercial interest in carbon nanotubes (CNTs) is reflected in a production capacity that presently exceeds several thousand tons per year. Currently, bulk CNT powders … |
Michael F L De Volder; Sameh H Tawfick; Ray H Baughman; A John Hart; |
| 2013 | 9 | The Microbial Metabolites, Short-chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Regulatory T cells (Tregs) that express the transcription factor Foxp3 are critical for regulating intestinal inflammation. Candidate microbe approaches have identified bacterial … |
PATRICK M SMITH et. al. |
| 2013 | 10 | Sleep Drives Metabolite Clearance from The Adult Brain IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic … |
LULU XIE et. al. |
| 2012 | 1 | A Programmable Dual-RNA-guided DNA Endonuclease in Adaptive Bacterial Immunity IF:10 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems provide bacteria and archaea with adaptive immunity against viruses and plasmids … |
MARTIN JINEK et. al. |
| 2012 | 2 | Efficient Hybrid Solar Cells Based On Meso-superstructured Organometal Halide Perovskites IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The energy costs associated with separating tightly bound excitons (photoinduced electron-hole pairs) and extracting free charges from highly disordered low-mobility networks … |
Michael M Lee; Joël Teuscher; Tsutomu Miyasaka; Takurou N Murakami; Henry J Snaith; |
| 2012 | 3 | Host-gut Microbiota Metabolic Interactions IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and … |
JEREMY K NICHOLSON et. al. |
| 2012 | 4 | Cyclic GMP-AMP Synthase Is A Cytosolic DNA Sensor That Activates The Type I Interferon Pathway IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers host immune responses such as the production of type I interferons. Cytosolic DNA induces … |
Lijun Sun; Jiaxi Wu; Fenghe Du; Xiang Chen; Zhijian J Chen; |
| 2012 | 5 | Photoacoustic Tomography: in Vivo Imaging from Organelles to Organs IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Photoacoustic tomography (PAT) can create multiscale multicontrast images of living biological structures ranging from organelles to organs. This emerging technology overcomes the … |
Lihong V Wang; Song Hu; |
| 2012 | 6 | Interactions Between The Microbiota and The Immune System IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The large numbers of microorganisms that inhabit mammalian body surfaces have a highly coevolved relationship with the immune system. Although many of these microbes carry out … |
Lora V Hooper; Dan R Littman; Andrew J Macpherson; |
| 2012 | 7 | Laser Scribing Of High-performance And Flexible Graphene-based Electrochemical Capacitors IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Although electrochemical capacitors (ECs), also known as supercapacitors or ultracapacitors, charge and discharge faster than batteries, they are still limited by low energy … |
Maher F El-Kady; Veronica Strong; Sergey Dubin; Richard B Kaner; |
| 2012 | 8 | Spin-torque Switching With The Giant Spin Hall Effect Of Tantalum IF:10 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Spin currents can apply useful torques in spintronic devices. The spin Hall effect has been proposed as a source of spin current, but its modest strength has limited its … |
LUQIAO LIU et. al. |
| 2012 | 9 | Systematic Localization of Common Disease-associated Variation in Regulatory DNA IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Genome-wide association studies have identified many noncoding variants associated with common diseases and traits. We show that these variants are concentrated in regulatory DNA … |
MATTHEW T MAURANO et. al. |
| 2012 | 10 | Signatures Of Majorana Fermions In Hybrid Superconductor-semiconductor Nanowire Devices IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Majorana fermions are particles identical to their own antiparticles. They have been theoretically predicted to exist in topological superconductors. Here, we report electrical … |
V MOURIK et. al. |
| 2011 | 1 | Electrical Energy Storage For The Grid: A Battery Of Choices IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The increasing interest in energy storage for the grid can be attributed to multiple factors, including the capital costs of managing peak demands, the investments needed for grid … |
Bruce Dunn; Haresh Kamath; Jean-Marie Tarascon; |
| 2011 | 2 | Light Propagation With Phase Discontinuities: Generalized Laws Of Reflection And Refraction IF:10 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Conventional optical components rely on gradual phase shifts accumulated during light propagation to shape light beams. New degrees of freedom are attained by introducing abrupt … |
NANFANG YU et. al. |
| 2011 | 3 | Two-dimensional Nanosheets Produced By Liquid Exfoliation Of Layered Materials IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: If they could be easily exfoliated, layered materials would become a diverse source of two-dimensional crystals whose properties would be useful in applications ranging from … |
JONATHAN N COLEMAN et. al. |
| 2011 | 4 | Linking Long-term Dietary Patterns With Gut Microbial Enterotypes IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 … |
GARY D WU et. al. |
| 2011 | 5 | Porphyrin-sensitized Solar Cells With Cobalt (II/III)-based Redox Electrolyte Exceed 12 Percent Efficiency IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The iodide/triiodide redox shuttle has limited the efficiencies accessible in dye-sensitized solar cells. Here, we report mesoscopic solar cells that incorporate a … |
ASWANI YELLA et. al. |
| 2011 | 6 | Carbon-based Supercapacitors Produced By Activation Of Graphene IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Supercapacitors, also called ultracapacitors or electrochemical capacitors, store electrical charge on high-surface-area conducting materials. Their widespread use is limited by … |
YANWU ZHU et. al. |
| 2011 | 7 | The Future Of Seawater Desalination: Energy, Technology, And The Environment IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: In recent years, numerous large-scale seawater desalination plants have been built in water-stressed countries to augment available water resources, and construction of new … |
Menachem Elimelech; William A Phillip; |
| 2011 | 8 | Increasing Solar Absorption For Photocatalysis With Black Hydrogenated Titanium Dioxide Nanocrystals IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: When used as a photocatalyst, titanium dioxide (TiO(2)) absorbs only ultraviolet light, and several approaches, including the use of dopants such as nitrogen, have been taken to … |
Xiaobo Chen; Lei Liu; Peter Y Yu; Samuel S Mao; |
| 2011 | 9 | The Unfolded Protein Response: From Stress Pathway To Homeostatic Regulation IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: The vast majority of proteins that a cell secretes or displays on its surface first enter the endoplasmic reticulum (ER), where they fold and assemble. Only properly assembled … |
Peter Walter; David Ron; |
| 2011 | 10 | A Perspective On Cancer Cell Metastasis IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Metastasis causes most cancer deaths, yet this process remains one of the most enigmatic aspects of the disease. Building on new mechanistic insights emerging from recent … |
Christine L Chaffer; Robert A Weinberg; |
| 2010 | 1 | Food Security: The Challenge Of Feeding 9 Billion People IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Continuing population and consumption growth will mean that the global demand for food will increase for at least another 40 years. Growing competition for land, water, and … |
H CHARLES J GODFRAY et. al. |
| 2010 | 2 | Materials And Mechanics For Stretchable Electronics IF:10 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Recent advances in mechanics and materials provide routes to integrated circuits that can offer the electrical properties of conventional, rigid wafer-based technologies but with … |
John A Rogers; Takao Someya; Yonggang Huang; |
| 2010 | 3 | Fate Mapping Analysis Reveals That Adult Microglia Derive From Primitive Macrophages IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Microglia are the resident macrophages of the central nervous system and are associated with the pathogenesis of many neurodegenerative and brain inflammatory diseases; however, … |
FLORENT GINHOUX et. al. |
| 2010 | 4 | Global Biodiversity: Indicators Of Recent Declines IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: In 2002, world leaders committed, through the Convention on Biological Diversity, to achieve a significant reduction in the rate of biodiversity loss by 2010. We compiled 31 … |
STUART H M BUTCHART et. al. |
| 2010 | 5 | Lipid Rafts As A Membrane-organizing Principle IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Cell membranes display a tremendous complexity of lipids and proteins designed to perform the functions cells require. To coordinate these functions, the membrane is able to … |
Daniel Lingwood; Kai Simons; |
| 2010 | 6 | A Draft Sequence Of The Neandertal Genome IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of Europe and western Asia before disappearing 30,000 years ago. We present a draft … |
RICHARD E GREEN et. al. |
| 2010 | 7 | Induction Of Colonic Regulatory T Cells By Indigenous Clostridium Species IF:10 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: CD4(+) T regulatory cells (T(regs)), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, … |
KOJI ATARASHI et. al. |
| 2010 | 8 | Reconstituting Organ-level Lung Functions On A Chip IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Here, we describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. This bioinspired microdevice reproduces … |
DONGEUN HUH et. al. |
| 2010 | 9 | Ultrahigh Porosity In Metal-organic Frameworks IF:9 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: Crystalline solids with extended non-interpenetrating three-dimensional crystal structures were synthesized that support well-defined pores with internal diameters of up to 48 … |
HIROYASU FURUKAWA et. al. |
| 2010 | 10 | Climate Change Will Affect The Asian Water Towers IF:8 Summary Related Papers Related Patents Related Grants Related Venues Related Experts View Abstract: More than 1.4 billion people depend on water from the Indus, Ganges, Brahmaputra, Yangtze, and Yellow rivers. Upstream snow and ice reserves of these basins, important in … |
Walter W Immerzeel; Ludovicus P H van Beek; Marc F P Bierkens; |